gsk a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T25471	GSK-A	GSK A
	GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.
T1881	AR-A014418	AR 0133418,GSK-3beta Inhibitor VIII,AR 014418,GSK 3β inhibitor VIII	GSK-3
	AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.		GSK-3
T27499	GSK-A1		HCV Protease , PI4K
	GSK-A1 is a specific inhibitor of PI4KA, also inhibited calcium-driven PRL secretion without affecting calcium signaling and Prl expression. GSK-A1 has anti-hepatitis C virus (HCV) potential.		HCV Protease , PI4K
T10202	A 1070722		GSK-3
	A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for...		GSK-3
T1906	Molibresib	GSK 525762A,GSK525762,I-BET 762	Epigenetic Reader Domain
	Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).		Epigenetic Reader Domain
T7361	Verucerfont	NBI77860,GSK561679	CRFR
	Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .		CRFR
T24106	GSK2163632A	GSK-2163632-A,GSK 2163632 A
	GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.
T25468	GSK1829820A	GSK-1829820-A,GSK 1829820A,GSK 1829820 A,GSK-1829820A
	GSK1829820A is a Mycobacterium tuberculosis H37Rv non-cytotoxic inhibitor.
T27470	GSK-2878175	GSK-175,GSK 175 A,GSK-175-A,GSK 175
	GSK-2878175, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
T70170	Milvexian TFA
	Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 ...
T24708	Remogliflozin	GSK189074,Remogliflozin A,GSK-189074,GSK 189074
	Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively).
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T9025	KY19382	2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382,A3051	Others , GSK-3 , Wnt/beta-catenin
	KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It...		Others , GSK-3 , Wnt/beta-catenin
T64366	GSK3-IN-4		GSK-3
	GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.		GSK-3
T60472	GSK-3β inhibitor 12		GSK-3
	GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β inhibitor 12 can be used for the study of Parkinson's in the pre...		GSK-3
T9611	PF-04802367		GSK-3
	PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ...		GSK-3
T22657	Laduviglusib trihydrochloride	CT99021 trihydrochloride,CHIR 99021 trihydrochloride,CHIR 99021 trihydrochloride (252917-06-9 free base)	GSK-3 , Wnt/beta-catenin
	Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-...		GSK-3 , Wnt/beta-catenin
T11471	GSK-3β inhibitor 2	5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-	GSK-3
	GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Al...		GSK-3
T67856	GSK-3β inhibitor 14	1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-	GSK-3
	GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.		GSK-3
T6129	GSK-1070916	GSK-1070916A,GSK1070916	Apoptosis , Tie-2 , FLT , AMPK , Aurora Kinase
	GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.		Apoptosis , Tie-2 , FLT , AMPK , Aurora Kinase